Case study · Life sciences
The immune response to severe COVID-19, cell by cell
Which immune cells carry the interferon response in severe COVID-19, and how does it differ from severe influenza?
Every citation lights the exact records behind it
The Space
COVID-19 PBMC
59,572 blood immune cells from 20 samples: healthy donors, asymptomatic to severe COVID-19 and severe influenza, clustered by cell type, with each patient's clinical measurements and interferon and TNF/IL-1 programme scores.
Source: CZ CELLxGENE Discover (CC BY 4.0); Lee et al., Science Immunology 5, eabd1554 (2020).
59,572 records
Largest clusters in the map sample
- Classical monocytes33%
- NK cells17%
- CD8 T cells12%
- B cells (IgG-)7%
- Platelets7%
- CD8 effector-memory T7%
- CD4 effector-memory T6%
- CD4 T cells4%
On the map
What to look for
- Classical monocytes form the largest cluster; their interferon and TNF/IL-1 programme scores separate the diagnoses.
- T, NK and B cells sit in their own regions, so a selection by cell type is one lasso.
- Every cell carries its donor’s clinical measurements, so a cluster can be split by severity in place.
With Mantis
What to ask
- Which cell types score highest on the interferon programme in severe COVID-19?
- Compare classical monocytes between severe COVID-19 and severe influenza.
- Which clinical measurements track the TNF/IL-1 programme?
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